2. Aacharya Priyavat Sharma – Dravyaguna Vidnyana, part-2, edition – reprinted 2005, published by - Chaukhamba Sanskrit Sansthan Varanasi, page no.- 704.
3. Murali B, Upadhyaya UM, Goyal RK. Effect of chronic treatment with Enicostemma littorale in non-insulin dependent diabetic rats. J Ethnopharmacol 2002; 81: 199-204.
4. Ambikadatta Shastri – Sushruta Samhita, Nidanasthana 6, Pramehanidana Adhyaya, edition - reprinted 2001, published by - Chaukhamba Sanskrit Sansthan Varanasi, page no.- 255.
5. Yadavji Trikamji, Charaka Samhita - Agnivesha revised by- Charaka and Dridhabala with Dipika commentary of Chakrapanidatta. Nidansthan 06, Pramehnidan Adhyaya, Reprinted 2005, Published by – Chaukhamba Sanskrit Sansthan Varanasi;
6. www.ijdr.in. Diabetes: Mechanism, pathophysiology and management - A Review.
7. Sathishkumar R, Lakshmi PTV, Annamalai A. Effect of drying treatment on the content of antioxidants in Enicostemma littorale Blume. Res J Med Plant 2009; 3(3): 93-101
8. Garad MC, Upadhya MA, Kokare DM, Itankar PR. Aerial parts of Enicostemma littorale Blume serve as anti-pyretic and antacid: in vivo and in vitro evaluations. Pharmacogn commun 2012; 2(3): 42-45.
9. Dymoc W, Warden CJH, Hooper D. Pharmacographica indica , Calcutta:Thacker, Spink & Co.; 1893, vol 2, p. 516
10. Ghosal SS, Sharma AK, Chaudhuri PV. Chemical constituents of Gentianaceae 9; natural occurrence of erythrocentaurin in Enicostemma hissopifolium and Swertia lawii. J Pharm Sci 1974; 63: 944-945
11. Jhan E, Perveen S, Malik A. Verticilliside, a new flavones C-glucoside from Enicostemma verticilliside. J Asi Nat Prod Res 2009; 11: 257-260
12. Leelaprakash G, Mohan Dass S. Antimicrobial activity and phytochemical screening of methanol extract of Enicostemma axillare. Int J Pharm Sci 2012; 4(1): 342-348
13. Desai PD, Ganguly AK, Govindachari TR, Joshi BS, Kamat VN, Manmade AH, et al. Chemical investigation of some Indian medicinal plants: part 2 Ind J Chem 1966: 4: 457-459
14. Sathiskumar R, Lakshmi PTV, Annamalai A. Comparative Analyses of non enzymatic and enzymatic antioxidants of Enicostemma littorale Blume. Int J Pharma Bio Sci 2010; 1(2): 1-16
15. https://sites.google.com and Enicostema axillare – eflorafindia.
16. https://08511630493324166816.googlegroups.com, cited on 14 Feb. 2018
17. Aacharya Priyavat Sharma – Dravyaguna Vidnyana, part-2, edition – reprinted 2005, published by - Chaukhamba Sanskrit Sansthan Varanasi, page no.- 704.
18. Yadavji Trikamji, Charaka Samhita - Agnivesha revised by - Charaka and Dridhabala with Dipika commentary of Chakrapanidatta. Sutrasthana, 26, Aatreyabhadrakapyiya Adhyaya, Reprinted 2005, Published – Chaukhamba Sanskrit Sansthan Varanasi; page no. 368
19. Ambikadatta Shastri – Sushruta Samhita, Sutrasthana 41, Dravyavisheshvidnyaniya Adhyaya, edition - reprinted 2001, published by - Chaukhamba Sanskrit Sansthan Varanasi, page no.- 154.
20. Jyoti, M., Vasu, V. T. Ravikumar, A and Sarita, G. Glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes a possible mechanism of action. Journal of Ehnopharmacol, 2000; 81: 199-204.
21. Jyoti Maroo, Arna Ghosh, Rajni Mathur, Vihas T. Vasu and Sarita Gupta. Antidiabetic efficacy of Enicostemma littorale Methanol extract in Alloxan-induced diabetic rats. Pharmaceutical Biology. 2003, Vol. 41, No. 5, pp. 388-391.
22. Jyoti, M., Vasu, V.T. and guptam, S. Dose dependent hypoglycemic effect of aqueous extract of Enicostemma littorale blum in alloxan induced diabetic rats. Phytomedicine, 2003; 10: 196-199.
23. Maroo J, Vasu VT, Aalinkeel R, Gupta S (2002): glucose lowering effect of aqueous extract of Enicostemma littorale Blume in diabetes: A possible mechanism of action. J Ethnopharmacol 81: 317-320.
24. Maroo J., V. T. Vasu S. Gupta Dose dependent hypoglycemic effect of aqueous extract of E. littorale Blume in alloxan induced diabetic rats, Phytomedicine, 2003; 10: 196-199.
25. Vishwakarma Santosh L. Bagul Milind S. Rajani M. Goyal Ramesh K. A sensitive HPTLC method for estimation of swertiamarin in E. littorale blume, Journal of planar chromatography, 2004; 17: 128-131.
26. Upadhyaya UM, Goyak RK. Efficacy of E. littorale in type 2 diabetic patients. Phyto Res 2004; 18: 233-235
27. Prince PSM, Srinivasan M. Enicostemma littorale Blume aqueous extract improves the antioxidant status in alloxan induced diabetic rat tissues. Acta Pol Pharm Drug Res 2005; 62(5): 363-367.
28. Jaishree Vaijanathappa, Shrisshailappa Badami and Suresh Bhojraj, Invitro anti-oxidant activity of Enicostemma axillare, Journal of Health Science, 2008; 54: 524-528.
29. Gite VN, Pokharkar RD, Chopade VV, Takate SB. Hepatoprotective activity of Enicostemma axillare in paracetamol induced hepatotoxicity in albino rats. Int J Phar life Sci 2010; 1(2): 50-53.
30. Sarita Gupta, Nidheesh Dadheech, Anubha Singh, Sanket Soni and R R Bhonde, Enicostemma littorale: A new therapeutic target for islet neogenesis, International Journal of Integrative Biology, 2010; 10: 49-53.
31. Shukla Amarnath, Shukla HM. Single blind placebo contolled clinical evaluation of mamajjaka ghanvati in prameha with special reference to diabetes mellitus. Journal of Ayurveda and Holistic Medicine, 2013; 1(5): 11-9.
32. Gohil Ta, Patel JK, Vaghasiya JD, Mane ant hyperglycemic and antihyperinsulinemic effect of aqueous extract of Aegle marmelos leaf and Enicostemma littorale, Ind J Pharm, 2008; 40(2): 66-91.
33. Gopal R, A. Gnanamani, R. Udayakumar and S. Sadulla. Enicostemma littorale Blume a potential hypolipidaemic plant, Natural Product Radiance, 2004; 3: 401-405.
34. Vihas T. Vasu, Hiren Modi, Jyoti v. Thaikoottathil and Sarita Gupta, Hypolipidaemic and antioxidant effect of Enicostemma littorale Blume. Aqueous extract in cholesterol fed rats, Journal of Ethnopharmacology, 2005; 101: 277-282.
35. Hitesh Vaidya, Mandapati Rajani, Vasudevan Sudarsanam, Harish Padh, Ramesh Goyal, Swertiamarin: A lead from Enicostemma littorale Blume for antihyperlipidaemic effect, 2009; 617:108-112.
36. Gupta R.S., and Dharmendra Singh, Hepatomodulatory role of Enicostemma littorale Blume against oxidative stress induced liver injury in rats, African Journal of Agricultural Research, 2007; 2: 131-138.
37. Natarajan PN, Prasad S: Chemical investigation of E. littorale. Planta Med, 2002, 22: 42-46.
38. Ghosal S, Jaiswal DK: Chemical constitution of Gentianaceae 28: Flavonoids of E. hyssopifolim (Wild) Verd. J Pharm Sci 1: 53-56.
39. Bhatt NM, Barua S, Gupta S. Protective effect of Enicostemma littorale Blume on rat model of diabetic neuropathy. Am J Infect Dis 2009; 5(2): 106-112.
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© Ayurlog: NJ-RAS, 2018
Dr. Pranita Pravin Mali
BAMS, PG Scholar 2nd year, Dravyaguna vidnyan, Government Ayurved College, Osmanabad
D. V. Kulkarni
Affiliation not stated
D. B. More
Affiliation not stated
How to Cite
UNDERSTANDING THE PHARMACOKINETICS OF MAMAJJAKA (ENICOSTEMMA LITTORALE BLUME) AS A DIETARY SUPPLEMENT IN DIABETES MELLITUS.
Vol 6 No 3 (2018): AYURLOG: NJRAS | April 2018
Submitted: Apr 19, 2018
Published: Apr 25, 2018
Enicostemma littorale Blume, also known as Mamajjaka in Sanskrit, Indian gentian in English and “Kadavinay” in local language, is a perennial herb of Gentianaceae family. The plant parts like leaves and roots are used since ages in various parts of India for treating diabetes. It is widely used in Solapur and Osmanabad districts of Maharashtra, in the form of “leaf pickle” as a dietary supplement in diabetic patient. Acharya Priyavat Sharma has described it as useful in madhumeha. Mamajjaka has a predominance of Tikta rasa, Ushna virya, Katu vipaka, Laghu-Ruksha guna and Vayu-Aakash mahabhuta. It’s an easily available and economically important herb. Different constituents of Mamajjaka, like Swertiamarin, Flavonoids, Saponins, triterpenoids, alkaloids, catechins, sterols, phenolic acids and xanthones, have been reported for possessing hypoglycemic properties. In-vivo, anti-hyperglycemic effect of Mamajjaka has been established, through enhancing glucose-induced insulin release, reducing the glycosylated hemoglobin and by inhibiting the action of glucose-6-phosphate in liver. As, all previous studies have established the significant potentials of Mamajjaka both in Type-1 and Type-2 diabetes, in this study we have reviewed the pharmaco-kinetics of Mamajjaka, keeping in mind the scientific basis of traditional use of Mamajjaka mainly as diet in diabetes. We have established the role of panchabhautic constitution of Mamajjaka as a dietary supplement for the diabetic patients. We have concluded that Mamajjaka, being cost-effective and easily available medicinal herb possessing hypoglycemic properties, can be used as an excellent vegetable in diabetic patients as a dietary supplement.