About santarpanjanya Vikaras1like Sthaulya/Medoroga, Prameha, Hridroga Ayurveda presumes that faulty dietary habits and lifestyle errors in accordance with genetic make of an individual alters functions of different sets of Agni (especially Medodhatvagni), which may leads to defective tissue metabolism at one side and formation of Ama (reactive antigenic factor) like substances at other sites. Medhodhatvagni Mandata & Medodhatvagniansa vridhi2 increases the fatty contents in the body and Dhatus and Ama precipitate and initiates process of inflammation that laid down the backbone of basic matrix metabolic disorders including metabolic syndrome and Prediabetes. In the present study is design to find out exact nidan and samprapti ghatak of the two clinical conditions.