Kauarbhritya is a branch of Ashtanga Ayurveda that defines a unique concept regarding disease caused by unidentified vectors known as Balagraha. Unfortunately it is abandoned in today’s era due to its mythological explanation which kept evidences far away from scientific justification. Therefore an effort has been done with an aim to understand Bala graha on modern parameters as well as its clinical application in day to day practice. Material for the present review was collected from Ayurvedic textbooks. After thorough study of the concept of balagraha it is concluded that these unidentified vectors are thought to be microbes which cannot be seen by naked eyes but produce group of diseases of multi systemic-origin and syndromes.