Agadtantra is the sixth branch of ayurveda which mainly deals with agada i.e. the medicine with antipoisonous effects. These antipoisonous drugs are prepared by combination of several drugs. Various medicinal plants are described in ayurveda which are used in the treatment of poisoning (Visha), one of them is aparajita. In bhavprakash nighantu and kaiyadev nighantu it is mentioned as ‘vishapaha’ which alleviates toxins. In sushruta samhita it is included in arkadi gana which is also vishapaha i.e. which eliminates poison. Pharmacological activities of aparajita like nephroprotective, diuretic, hepatoprotective, anti inflammatory, antihistaminic are proved. The roots, flowers, seeds and leaves are used for medicinal purpose both internally as well as externally. This review is small attempt to explore its antipoisonous formulations and antipoisonous activity.