Osteoporosis is a skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. Modern medicines have its own limitations in treating osteoarthritis and have many adverse effects with its prolonged use. Hence Ayurveda which is well known for treating chronic diseases and providing a safe therapy is proved a noble management for treating Osteoporosis. In this study a female patient aged 50 years was admitted in IPD of Panchakarma with complaints of bilateral knee joint pain, crepitus, restricted movements and general weakness since one year. She was a diagnosed case of Osteoporosis. Vasti Chikitsa is considered as half the treatment for Vata dominated diseases, for its Vata Shamaka properties, proved better in the Management of osteoporosis (Asthikshaya). ASTHISHRIKLA is an ayurvedic herb used for strengthening bones and joints and promoting bone growth. It increases bone mineral density and enhances the rate of fracture healing. Hence ASTHISHRIKLA GHRIT MATRA VASTI (60ml) was given to the patient as treatment for a period of 21 days. This treatment showed marked improvement in all parameters i.e. pain and swelling was reduced, stiffness reduced, gait improved, range of movements increased.