Ayurveda is God’s gift for wellbeing of human kind. Today wholeworld is looking towards ayurveda as a best therapeutic option for worst skin disorders. Skin is the largest and first site visible organ of body acquiring two square meter of surface area & accounting 16-20% of body weight.1 InAyurvediyaSamhitas skin is described as Twacha various opinion regarding  Twachauttapati, Twachastara& associated disorders are mentioned.Twacha is described in samhitas as a protective layer of body. Sushrutacharya andCharakacharya have described various layers of ‘Twak’ or skin, 7 & 6 layers respectively, and the diseases specific to them.When life induced by union of Sperm (Shukra) and ovum (Shonita) in uterus (garbhashaya) it undergoes rapid transformation and formation and seven layers of skin form during embryonic period in third and fifth month of fetal age Modern science has also explained skin and diseases occuring in skin.This paper deals with disease occuring in different   layers oftwacha (skin), as per Ayurved& Modern science.