Despite the advancements in diagnostic techniques and therapeutic interventions, medical science has failed to keep the incidence of congenital malformations under control. Ayurveda, the ancient Indian medical system has given due emphasis on this and postulated various measures to minimize the risks. Ayurvedic Acharyaâ€™s has great knowledge about genetics. The conglomeration of the six procreative factors (Shad Garbhkara Bhavas) such as Matrija, Pitrija, Aatmaja, Rasaja, Satmyaja, and Sattvaja is must for healthy progeny. The physical, mental, social, and spiritual well-being of the person, proper nutrition of the mother during pregnancy, and practice of a wholesome regimen, play a prime role in achieving a healthy offspring, thus structuring a healthy family, society, and nation. Present article focuses on various congenital and genetic anomalies in Ayurveda on the basis of modern scientific knowledge.