Ayurveda is one of the old traditional science which deals with healthy and diseased state of human beings through lifestyle, dietary supplements, medication, yoga, purification techniques. In decades of old age can be reduced by the rasayana therapy, which is the line of treatment for vriddha age groups with dominant of vata dosha, agni mandya, dhatu and upadhatu Kshaya. Women are mostly vulnerable at early stage by the vata dosha, dhatu Kshaya especially asthi dhatu, upadhatu like aartava etc. Kshaya of asthi dhatu in menopausal period can be considered as menopausal osteoporosis. Prevention is better than cure as per this proverb, this study was held to prevent the risk of postmenopausal osteoporosis with the drugs lashuna and shatavari treated in comparison method. By its guna of snigdha, vatahara, rasayana etc.