Hyperlipidemia is term used to denote raised serum levels of cholesterol or triglycerides or both. The lipid hypothesis proposed by Rudolph Virchow in 1856 suggested that blood lipid accumulation in arterial walls caused atherosclerosis. There is no precise term for hyperlipidemia in the Ayurvedic classics. Yet various scholars have tried use distinct nomenclature for hyperlipidemia, e.g., Rasagata Sneha Vriddhi, Rasa Raktagata Sneha Vriddhi, Dhamani Pratichayah, Medovriddhi, Medoroga or Medodosha, Ama Medo Dhatu, etc. A detailed study of hyperlipidemia reveals its similarity to Asthayi Medo Dhatu Vriddhi with regard to the pathophysiology. Also, this excessively increased Asthayi Medo Dhatu is Ama in nature, due to which it is retained in the body for a longer time, resulting in further complications. From the Ayurvedic point of view hyperlipidemia is a result of Santarpana. Acharya Charaka has stated that regular administration of Guggulu as a formulation can cure all the Santarpanjanya Vyadhis or diseases due to overnutrition.  Considering the lack of definite Ayurveda comprehension of hyperlipdemia, as well as the role of hyperlipidemia in the causation life-threatening diseases, we carried out this study to evaluate the efficacy of Guggulu Ghanavati in the management of hyperlipidemia.
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