Dyslipidemia is burning issue in front of society. Due to change in dietary habits & unhealthy life study it is significantly observed across the globe. To keep in mind this study was designed. Aim of this study was to compare Medosara & Medovriddhi with special reference to lipid profile. For this study 30 Medosara presons were selected & 30 Medovriddhi patients were selected from OPD. In both cases lipid profile was carried. The comparison was done on the basis of lipid profile in both groups. The result was nonsignificant in triglycerides level but it was significant in serum cholesterol level & highly significant in HDL & LDL level. Conclusion of study is by evaluating lipid profile Medovriddhi and Medosarata can be identify to a significant extent.