Dravya Pariksha plays a vital role in the field of clinical Ayurveda. It elaboratively deals with the study of Ayurvedic parameters to assess Rasapanchaka (Rasa, Virya, Vipaka, Guna, Prabhav) of a herbal drug that helps in evaluating its efficacy and probable mode of action. Ayurvedic texts comprise of detailed guidelines to find out Rasapanchaka of Anukta (undocumented) as well as time tested herbal drugs. However, in this article, an attempt has been made to understand the analysis of Rasapanchaka of a drug by incorporating modern parameters. A brief review of utilising methods like Taste threshold assessment to find Rasa & anurasa of the drug, Endothermic & exothermic reaction methods to find out Virya, modern clinical parameter like body temperature to assess Ushna or Sheeta Guna of a certain Aushadhi or Ahar dravya and so on has been discussed. Added advantage of studying these parameters will help in avoiding language barriers since, it will become more easier to describe Ayurvedic concepts written in Sanskrit. Thus, it can be concluded that studying a new or already documented herbal drug by combining both Ayurvedic and Modern parameters may be more beneficial & scientifically acceptable.