In Ayurveda Aacharya Sushruta ‘father of ancient surgery’ has described the types of Vrana according to healing stages i.e.Ruhyamana Vrana ,Shuddha Vrana and Dushta Vrana on the basis of ancient pathophysiology of wound. In Dushta Vrana healing process is delayed due to infection. Aacharya Sushruta already mentioned various ways of application of drugs over Vrana i.e. in the form of “Pichu, Kawalika, Varti and Vikeshika”.Aacharya Vagbhata also mentioned the function of “VIKESHIKA” in Vrana.