Systemic lupus erythematosus (SLE) is a disease that can affect persons of all ages and ethnic groups and both sexes, but more than 90% of new patients presenting with SLE are women in the childbearing years. SLE is a disease that affects multiple systems. This article attempted to provide an overview of Autoimmunity from Ayurveda and modern perspective w. s. r. to Systemic Lupus Erythematosus. SLE can be correlated with Uttana and Gambhira Vatarakta based on sthana involved in pathogenesis and Raktadhika Vatarakta based on predominant doshas involved which presents similar symptoms as that of SLE. Further research on this less-explored topic is expected.
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